HCID 70362511, compound → HCID 54064958, compound

Participants

Reaction Steps

To an ethanolic solution (100 mL) of the diester from Step F (0.01 mol) is added 1N sodium hydroxide solution (30 mL). This mixture is stirred at ambient temperature until all of the diester is converted to the diacid. The product is isolated and purified by first removing the solvent then resuspending the solidified residue in water. This basic suspension is then made acid (pH 4 to 5) with dilute hydrogen chloride solution and the resulting solid isolated by filtration and air dried. This is then purified further by recrystallization to obtain pure 3-[2-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-1-hydroxy-2-((2-carboxyethyl)thio)ethyl]phenoxyacetic acid.

Provenance & Evidence