Benzylamine → HCID 18638658, compound

Participants

Reaction Steps

5 g (13.14 mmol) of Nα-benzyloxycarbonyl-Nε-tert.-butoxycarbonyl-L-lysine in 30 cm3 of dry DMF and 1.41 g (13.14 mmol) of benzylamine are condensed in the presence of 2.01 g (13.14 mmol) of hydroxybenzotriazole in 10 cm3 of dry DMF and 2.98 g (14.54 mmol) of dicyclohexylcarbodiimide in 10 cm3 of dry DMF. A pasty solid is obtained after treatment under the same conditions as for the preparation of the compound (5). This solid is covered with ether to give a precipitate of N-benzyl-Nα-benzyloxycarbonyl-Nε-tert.-butoxycarbonyl-L-lysinamide (5.51 g; 89%).

Provenance & Evidence