HCID 11744866, compound → HCID 136364588, compound

HRID 2073610Notes

Reaction equation

HRID 2073610 reaction equation
[C:1](/[C:4](=[CH:10]\[CH3:11])/[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=O)[CH3:2].[NH2:12][C:13]1[N:17]=[CH:16][NH:15][N:14]=1>C(O)C>[CH2:8]([O:7][C:5]([C:4]1[CH:1]([CH3:2])[N:14]2[N:15]=[CH:16][N:17]=[C:13]2[NH:12][C:10]=1[CH3:11])=[O:6])[CH3:9]

Participants

4

Reactant 2

HCID 11744866HCID 11744866, compoundHCID 178418311HCID 178418311, compound

Product 1

HCID 136364588HCID 136364588, compoundYield 63.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To 50 ml of ethanol are added 7.8 g of ethyl α-acetylcrotonate and 4.2 g of 3-amino-1,2,4-triazole, stirred at 50° C. for an hour and then heated under reflux for an hour. The ethanol is evaporated under reduced pressure, and the obtained crystals are recrystallized from ethanol to give 7 g of 6-ethoxycarbonyl-5,7-dimethyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, melting at 155°-157° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for an hour
  3. customThe ethanol is evaporated under reduced pressure
  4. customthe obtained crystals are recrystallized from ethanol

Sources & evidence

ORD record
ord-e1a75fc1942143d89efb560f8e0d6542
Source dataset
uspto-grants-1990_04
Patent number
US04918074

Reaction notes

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