HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 54466938, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 54466938 | HCID 54466938 | 94.8% |
Reaction Steps
A mixture of 112 g of 2-thiophenecarbaldehyde, 116 g of methyl acetoacetate, 770 ml of benzene, 4 ml of acetic acid and 3 ml of piperidine is heated under reflux for 2.5 hours under the condition of azeotropic dehydration. The benzene is evaporated under reduced pressure and the residual solvent is distilled off to give 199 g of methyl 2-acetyl-3-(2-thienyl)acrylate, boiling at 130°-160° C./0.2 mmHg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04918074 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-fbd7ca06ecd644dc99760cc8dfeb2261 |
| Source note | uspto-grants-1990_04 |