Bis(2-amino-1H-imidazole) sulphate → HCID 13589520, compound

HRID 2073616Notes

Reaction equation

HRID 2073616 reaction equation
S(O)(O)(=O)=O.[NH2:6][C:7]1[NH:8][CH:9]=[CH:10][N:11]=1.[C:12]([C:15](=[CH:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:16]([O:18][CH3:19])=[O:17])(=O)[CH3:13]>>[CH:21]1([CH:20]2[N:8]3[CH:9]=[CH:10][N:11]=[C:7]3[NH:6][C:12]([CH3:13])=[C:15]2[C:16]([O:18][CH3:19])=[O:17])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 135136Bis(2-amino-1H-imidazole) sulphateHCID 57150919HCID 57150919, compound

Product 1

HCID 13589520HCID 13589520, compound

Procedure

Crystals are obtained by reacting 6.8 of 2-aminoimidazole sulfate with 10.5 g of methyl 2-acetyl-3-cyclohexylacrylate in a similar manner as described in Example 13. Recrystallization from methanol gives 4.8 g of 5-cyclohexyl-6-methoxycarbonyl-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine, melting at 178° C.

Workup

  1. customCrystals are obtained
  2. customRecrystallization from methanol

Sources & evidence

ORD record
ord-8871048ee772462ca58bc13cd1722030
Source dataset
uspto-grants-1990_04
Patent number
US04918074

Reaction notes

Loading…