Methanol → HCID 13589522, compound

Participants

Reaction Conditions

Reaction Steps

In a mixture of 50 ml of acetone, 30 ml of methanol and 20 ml of water is dissolved 1.8 g of 5-[3-(2-methyl-1,3-dioxolan-2-yl)phenyl]-6-methoxycarbonyl-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine. The mixture is adjusted to pH 1 with p-toluenesulfonic acid and then heated at 60° C. for 3 hours. The solvent is distilled off and the residue is neutralized with sodium bicarbonate solution. The resulting white precipitations are collected by filtration and recrystallized from a mixture of ethanol and acetone to give 1.1 g of 5-(3-acetylphenyl)-6-methoxycarbonyl-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine, melting at 227°-229° C.

Provenance & Evidence