Water → HCID 136364589, compound

HRID 2073625Notes

Reaction equation

HRID 2073625 reaction equation
[BH4-].[Na+].[CH3:3][O:4][C:5]([C:7]1[C:8]([CH3:26])=[N:9][C:10]2[N:11]([N:23]=[CH:24][CH:25]=2)[C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]([F:22])([F:21])[F:20])=[O:6].O>CO>[CH3:3][O:4][C:5]([C:7]1[CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:21])([F:22])[F:20])[N:11]2[N:23]=[CH:24][CH:25]=[C:10]2[NH:9][C:8]=1[CH3:26])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 15718479HCID 15718479, compound

Product 1

HCID 136364589HCID 136364589, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

16 mg of sodium borohydride is added gradually to a solution of 17 mg of 6-methoxycarbonyl-5-methyl-7-(2-trifluoromethylphenyl)pyrazolo[1,5-a]pyrimidine in 1 ml of methanol with stirring and heating at 60° C. The reaction mixture is poured into water, extracted with ethyl acetate and dried. The solvent is removed and the residue is recrystallized from methanol to give 6-methoxycarbonyl-5-methyl-7-(2-trifluoromethylphenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine, melting at 209°-210° C.

Workup

  1. extractionextracted with ethyl acetate
  2. customdried
  3. customThe solvent is removed
  4. customthe residue is recrystallized from methanol

Sources & evidence

ORD record
ord-0bf180a3c1b344f49b5fef00b9e29c70
Source dataset
uspto-grants-1990_04
Patent number
US04918074

Reaction notes

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