Triethylamine → HCID 54303311, compound

Participants

Reaction Steps

The ethyl 4-chloroformylcinnamate can be prepared as follows: 10.05 g (50 mmols) of 4-bromobenzoic acid, 6.25 g (62.5 mmols) of ethyl acrylate, 12.6 g (125 mmols) of triethylamine, 0.1122 g (0.5 mmol) of palladium acetate and 0.608 g (2 mmols) of tri-o-tolylphosphine in 20 ml of toluene are boiled under reflux for 1.5 hours. The reaction mixture is extracted by shaking with 200 ml of 2N hydrochloric acid, and the crude product is filtered off and recrystallised from toluene. 10.1 g (92% of theory) of ethyl 4-carboxycinnamate are obtained in the form of white crystals; melting point 196°-197° C.

Provenance & Evidence