3-Cyanopyridine → HCID 6914802, compound

Participants

Reaction Steps

41.6 g (0.4 mole) nicotinic acid nitrile, 70.5 g (0.4 mole) D,L-cysteine hydrochloride monohydrate and 55.2 g (0.4 mole) potassium carbonate were heated in 500 ml methanol and 500 ml water for 6 hours at the boiling point. Then, the solvent was removed under reduced pressure, the residue taken up in 300 ml water, adjusted with concentrated hydrochloric acid to pH 5 and heated 45 minutes at the boiling point. After the mixture cooled off, 78.7 g (87% of theory) colorless product with a melting point of 195° C. were recovered by suction.

Provenance & Evidence