3-Cyanopyridine → HCID 18638691, compound

Participants

Reaction Steps

20.8 g (0.2 mole) nicotinic acid nitrile, 29.8 g (0.2 mole) D-penicillamine and 13.8 g (0.1 mole) potassium carbonate were heated in 350 ml methanol and 150 ml water for 6 hours at the boiling point. The mixture was acidified with concentrated hydrochloric acid to pH 4 and heated 45 minutes at the boiling point. After the mixture cooled off, 36.5 g (63% of theory) of the product precipitated as hydrochloride with a melting point of 164° C. [α]25D =+4.0° (c=2 in 1N NaOH)

Provenance & Evidence