Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2,6-Di(propan-2-yl)aniline--hydrogen chloride (1/1) | HCID 11183476 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 19857641 | HCID 19857641 | 182.7% |
Reaction Steps
19.1 g of bromine are added dropwise at 0° C. over 1 hour to a suspension of 24.1 g of 2,6-diisopropylaniline hydrochloride in 250 ml of 1,2-dichloroethane. The reaction mixture is stirred for 1 hour at 0° C. and then filtered. The filter residue is washed with 1,2-dichloroethane and then dried at 40° C. under vacuum, affording 36.8 g (97% of theory) of 4-bromo-2,6-diisopropylaniline hydrobromide in the form of yellow crystals which melt at 235°-237° C. after recrystallisation from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04918230 |
|---|
| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-6b020719a53f41429aafdc9642d38bd2 |
|---|
| Source note | uspto-grants-1990_04 |
|---|
