Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2,6-Di(propan-2-yl)aniline--hydrogen chloride (1/1) | HCID 11183476 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Product | HCID 19857641 | HCID 19857641 | 169.3% |
Reaction Steps
19.1 g of bromine are added dropwise at 70° C. over 2 hours to a suspension of 24.1 g of 2,6-diisopropylaniline hydrochloride in 150 ml of cyclohexane. The hydrogen chloride evolved in the course of this addition escapes continuously. The reaction mixture is cooled to 10° C. and then filtered. The filter residue is washed with cyclohexane and dried at 40° C. under vacuum, affording 34.1 g of 4-bromo-2,6-diisopropylaniline hydrobromide (99.9% of theory) in the form of yellow crystals of 98.7% purity and having a melting point of 234°-235° C. (compound 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04918230 |
|---|
| Source dataset | uspto-grants-1990_04 |
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| ORD ID | ord-76f9ba5c09664218a24519271b791d10 |
|---|
| Source note | uspto-grants-1990_04 |
|---|
