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Dimethylformamide → 1-[(3-Methylbutoxy)methyl]-3-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | alpha-Chloro-m-nitrotoluene | HCID 12078 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Isoamyl Alcohol | HCID 31260 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-[(3-Methylbutoxy)methyl]-3-nitrobenzene | HCID 14330147 | — |
反応手順
Into a mixture of 500 ml (4.59 mol) of 3-methyl-1-butanol and 140 ml of dimethylformamide, 158.1 g (0.92 mol) of 3-chloromethylnitrobenzene was dissolved, and 78 g (1.39 mol) of potassium hydroxide pellets was added to the thus formed solution while cooling with water under a vigorous stirring. The temperature of the reaction mixture rised to 43° C. and then dropped slowly to room temperature. Thereafter, the reaction mixture was stirred for 7 hours at room temperature to complete the reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04919707 |
| 出典データセット | uspto-grants-1990_04 |
| ORD ID | ord-f1b386a450db4221819a68079da793cd |
| 出典メモ | uspto-grants-1990_04 |