Pyridine → HCID 54329672, compound

Participants

Reaction Steps

A solution of 11.5 g of 3-(5-methylfuran-2-yl)-propenyl chloride in 30 ml of absolute tetrahydrofuran was cooled to 0° to 5° C., and 4.2 g of propargyl alcohol and 20 ml of pyridine were added. The mixture was stirred for 12 hours at room temperature, the precipitated hydrochloride was filtered off and concentrated under reduced pressure, and the concentrate taken up in 200 ml of ethyl acetate and 50 ml of water. After washing three times with water, drying over Na2SO4 and removal of the solvent under reduced pressure, the residue was purified chromatographically (toluene/ethyl acetate=1/2). There was obtained 10.9 g of propargyl 3-(5-methylfuran-2-yl)-propenoate; refractive index nD26 =1.578.

Provenance & Evidence