Sodium Carbonate → HCID 135618014, compound

Participants

Reaction Steps

In 100 ml glacial acetic acid was dissolved 4.75 g 4,5-dihydro-3H-isoxazolo[5,4,3-kl]acridine. To the mechanically stirred solution under nitrogen was added 2.84 g of sodium cyanoborohydride. The reaction was complete after 0.5 hour at room temperature. The reaction mixture was neutralized with excess aqueous sodium carbonate and extracted with dichloromethane (DCM). The DCM was dried over MgSO4, filtered and concentrated to a solid. The solid was purified by flash chromatography and recrystallized from 1:1 DCM/hexanes to yield 2.78 g of powder, m.p. 152°-154° C.

Provenance & Evidence