Formaldehyde → alpha-[(Dipropylamino)methyl]-3,4,5-trimethoxybenzeneacetonitrile

HRID 2073725Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]#[N:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].Cl.[CH2:17]([NH:20][CH2:21][CH2:22][CH3:23])[CH2:18][CH3:19].[CH2:24]=O>>[CH2:17]([N:20]([CH2:24][CH:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:14]#[N:15])[CH2:21][CH2:22][CH3:23])[CH2:18][CH3:19]

Participants

Reactant 3

HCID 712Formaldehyde

HCID 258873,4,5-Trimethoxyphenylacetonitrile

HCID 12202988Dipropylamine Hydrochloride

Product 1

HCID 19855952alpha-[(Dipropylamino)methyl]-3,4,5-trimethoxybenzeneacetonitrile

Procedure

In a manner similar to Preparation 11 react 3,4,5-trimethoxybenzeneacetonitrile with dipropylamine hydrochloride and paraformaldehyde to obtain the title compound.

Workup

customIn a manner similar to Preparation 11

Sources & evidence

ORD record: ord-5bff80f39fa64e849beb7cb1563e0105
Source dataset: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04920116

Reaction notes

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