HCID 19856012, compound → HCID 135745116, compound

Participants

Reaction Steps

496 mg of 4-amino-3-(3-ethylphenyl)-5-isothiazolecarboxamide in 7 ml of glacial acetic acid, 4 ml of concentrated hydrochloric acid and 4 ml of N-methyl-pyrrolidone was stirred at 0° C. during the addition of 165 mg of sodium nitrite in 1 ml of water. The mixture was held at 0° C. for 1.5 hours then filtered and the solid residue was recrystallized from ethanol to give 400 mg of 7-(3-ethylphenyl)isothiazolo[4,5-d]-1,2,3-triazin-4(3H)-one, m.p. 156°-157° C. (dec.).

Provenance & Evidence