Ethanol → 6-Methoxy-1-methyl-1H-pyrazolo[3,4-b]quinolin-3-amine

HRID 2073776Notes

Reaction equation

HRID 2073776 reaction equation
[CH2:1](O)C.[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=C[C:10]([C:16]#[N:17])=[CH:9]2.[CH3:18][NH:19][NH2:20]>CO>[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:18]1[N:19]([CH3:1])[N:20]=[C:16]([NH2:17])[C:10]1=[CH:9]2

Participants

5

Reactant 3

HCID 702EthanolHCID 6061MethylhydrazineHCID 198561466-Methoxyquinoline-3-carbonitrile

Product 1

HCID 148224726-Methoxy-1-methyl-1H-pyrazolo[3,4-b]quinolin-3-amineYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Methoxy-1-methyl-1H-pyrazolo[3,4-b]quinolin-3-amine, orange crystals, m.p. 185°-186° C. (from ethanol) was prepared in 75% yield from 6-methoxy-3-quinolinecarbonitrile (Example 1c) and methylhydrazine in methanol.

Sources & evidence

ORD record
ord-ced0c3b3bf1e46cda379cb77008698e8
Source dataset
uspto-grants-1990_04
Patent number
US04920128

Reaction notes

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