Dimethylamine → HCID 14822490, compound

Participants

Reaction Conditions

Reaction Steps

To a saturated solution of dimethylamine in 250 ml methanol at 0° C. was added 4.5 g ethyl 3-amino-6-methoxy-1H-pyrazolo[3,4-b]quinolin-1-acetate (Example 20), and the mixture was stirred at 0° C. for one hour, at room temperature for 48 hours and at reflux for two hours. The reaction mixture was cooled to room temperature and the solid product was collected by filtration and chromatographed on silica gel using 95% chloroform/2.5% isopropyl alcohol/2.5% isopropylamine amine as eluant. The appropriate fractions were combined and evaporated to give 2.0 g 3-amino-6-methoxy-N,N-dimethyl-1H-pyrazolo[3,4-b]quinolin-1-acetamide, orange solid, m.p. 251°-253° C.

Provenance & Evidence