HCID 14822491, compound → HCID 14822492, compound

Participants

Reaction Steps

To a suspension of 2.00 lithium aluminum hydride in 100 ml tetrahydrofuran was added, portionwise, 5.5 g 3-amino-6-methoxy-N-methyl-1H-pyrazolo[3,4-b]quinolin-1-acetamide (Example 26) and 50 ml of tetrahydrofuran. The mixture was heated at reflux for 4 hours, then cooled and poured into ice-water. The solid product was collected and chromatographed on silica gel using 95% chloroform/5% isopropylamine as eluant. The fractions were combined and evaporated, and the product recrystallized from ether/hexane to give 0.77 g 1-[2-(methylamino)ethyl]-6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine, orange solid, m.p. 142°-144° C.

Provenance & Evidence