反应详情

To a solution of 15 g 7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine (Example 3d) in 190 ml ethanol was added 16 ml 47% aqueous dimethylamine and 6.5 ml 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature overnight, then concentrated by evaporation, and the residue was recrystallized from ethanol to give 10.8 g 1-[(dimethylamino)methyl]-7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine, bright-yellow solid, m.p. 156°-158° C.

1. concentrationconcentrated by evaporation
2. customthe residue was recrystallized from ethanol