1-Chloroethyl chloroformate → HCID 14822512, compound

HRID 2073792Notes

Reaction equation

HRID 2073792 reaction equation
[Cl:1][C:2]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[C:9]([O:15][CH3:16])[CH:8]=3)[N:4]([CH2:17][CH:18]([N:20](C)[CH3:21])[CH3:19])[N:3]=1.ClC(OC(Cl)C)=O>>[Cl:1][C:2]1[C:14]2[C:5](=[N:6][C:7]3[C:12]([CH:13]=2)=[CH:11][CH:10]=[C:9]([O:15][CH3:16])[CH:8]=3)[N:4]([CH2:17][CH:18]([NH:20][CH3:21])[CH3:19])[N:3]=1

Participants

3

Reactant 2

HCID 5213051-Chloroethyl chloroformateHCID 14822511HCID 14822511, compound

Product 1

HCID 14822512HCID 14822512, compound

Procedure

3-Chloro-1-[2-(methylamino)-2-methylethyl]-7-methoxy-1H-pyrazolo[3,4-b]quinoline was prepared by demethylation of 3-chloro-1-[2-(dimethylamino)-2-methylethyl]-7-methoxy-1H-pyrazolo[3,4-b]quinoline (Example 45), with α-chloroethyl chloroformate according to the procedure of Example 41, and was obtained in the form of a colorless solid, m.p. 98°-100° C.

Workup

  1. customwas obtained in the form of a colorless solid, m.p. 98°-100° C.

Sources & evidence

ORD record
ord-50927c14e0734b928ec281375a08be1d
Source dataset
uspto-grants-1990_04
Patent number
US04920128

Reaction notes

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