Hydrochloric Acid → HCID 14499840, compound

Participants

Reaction Steps

To a solution of 8-(2-methyl-6-t-butoxycarbonylaminobenzylamino)-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine (8.42 g) in ethanol (67 ml) was added dropwise 23%-ethanolic hydrogen chloride (26 g) at room temperature and the mixture was stirred for 6 hours. The resultant solid was siolated by filtration and dispersed into a mixture of an aqueous solution of sodium bicarbonate and chloroform. The chloroform layer was separated and washed with water and dried over magnesium sulfate. Following filtration, the solvent was removed under reduced pressure to give 8-(2-methyl-6-aminobenzylamino)-3-(2-propynyl)-2methylimidazo[1,2-a]pyridine (4.08 g). The crude crystzals (0.5 g) were recrystallized from a mixture of chloroform and n-hexane to give 0.46 g of pure crystals.

Provenance & Evidence