Potassium Carbonate → HCID 14499847, compound

Participants

Reaction Steps

To a solution of 8-[2-methyl-6-(3-benzoylthioureido)benzylamino]-3-(2propynyl)-2-methylimidazo[1,2-a]pyridine (0.59 g) in methanol (5.9 ml) and tetrahydrofuran (5.9 ml) was added a solution of potassium carbonate (0.174 g) in water (5 ml) and the mixture was stirred for 2 hours at room temperature. The solvent was removed under reduced pressure and the residue was dispersed into a mixture of water and chloroform. The chloroform layer was separated and washed with water and dried over magnesium sulfate. The residual oil was triturated with diethyl ether to give 8-(2-methyl-6-thioureidobenzylamino)-3-(2-propynyl)-2-methylimidazo[1,2-a]pyridine (0.36 g).

Provenance & Evidence