Lithium Hydroxide → HCID 14801346, compound

Participants

Reaction Steps

A solution of this 3,3-ethylenedioxy ester (4.73 g) in 50 ml of tetrahydrofuran is chilled to 0° C., treated with 10 ml of 1N lithium hydroxide in methanol and allowed to warm to room temperature. The reaction is monitored by thin layer chromatography. When all of the ester has been hydrolyzed, the solution is concentrated and diluted with ether. The mixture is washed three times with water and once with brine, dried over magnesium sulfate, and concentrated. The residue is crystallized from ethyl acetate/hexane to yield 3,3-ethylenedioxy-19,19-difluoroandrost-5-en-17β-ol as white crystals.

Provenance & Evidence