Monoethyl malonate → HCID 54287465, compound

HRID 2073828Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:9])[CH2:5][C:6]([OH:8])=O)[CH3:2].[Cl:10][C:11]1[C:12]([F:23])=[C:13]([C:17]([CH3:22])=[C:18]([F:21])[C:19]=1[F:20])[C:14](Cl)=[O:15]>>[Cl:10][C:11]1[C:12]([F:23])=[C:13]([C:17]([CH3:22])=[C:18]([F:21])[C:19]=1[F:20])[C:14]([C:6](=[O:8])[CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:9])=[O:15]

Participants

Reactant 2

HCID 70615Monoethyl malonate

HCID 21779773HCID 21779773, compound

Product 1

HCID 54287465HCID 54287465, compound

Procedure

The procedure outlined for Example H was used to prepare the title compound from the dianion of malonic acid monoethyl ester and 3-chloro-2,4,5-trifluoro-6-methylbenzoyl chloride. The crude product was also chromatographed on silica gel to give the desired product as an orange oil.

Sources & evidence

ORD record: ord-60a9d4cb6cb34bb58a4b3fbccc761359
Source dataset: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04920120

Reaction notes

Loading…