Hydrochloric Acid → HCID 23364527, compound

Participants

Reaction Steps

A solution of 1.12 g (11.0 mmol) of diisopropylamine in 5 ml of THF was cooled to 0° C. under nitrogen, treated with 4.0 ml of 2.5M n-butyllithium, and stirred for 10 minutes. This lithium diisopropylamide solution was added dropwise to a solution of 2.36 g (8 mmol) of 2-[2,4,5-trifluoro-3-(trifluoromethyl)-phenyl]-4,4-dimethyl-2-oxazoline in 5 ml of THF at -78° C. The solution was stirred at -78° C. for one hour, then quenched with 2.24 g (16 mmol) of methyl iodide. The mixture was allowed to warm slowly to room temperature, stirred for one hour, and poured into 10 ml of 1N HCl. This solution was extracted with ether, and the extract was washed with water, dried over magnesium sulfate, and concentrated to give 2.28 g of the title compound.

Provenance & Evidence