HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine → HCID 14651172, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Reactant | 1-Cyclopropyl-5-methyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14651258 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14651172 | HCID 14651172 | 74.9% |
Reaction Steps
A suspension of 0.80 g (2.69 mmol) of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acid, 1.08 g (10.8 mmol) of 2-methylpiperazine, and 20 ml of acetonitrile was refluxed for three hours, then cooled in an ice bath. The precipitate was filtered, washed with water and acetonitrile, and dried to give 0.76 g of the title compound, mp 187°-188° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920120 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-5c31add982424fd9bdf9ad86135e4259 |
| Source note | uspto-grants-1990_04 |