Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5-Acetyl-2-amino-6-methyl-3-pyridinecarbonitrile | HCID 14370123 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 14370125 | HCID 14370125 | — |
Reaction Steps
2.7 g (15.4 mmol) of 5-acetyl-2-amino-3-cyano-6-methyl-pyridine are suspended in 110 ml of glacial acetic acid, and 1.9 ml (16.2 mmol) of 48% strength HBr are added. Then 5.2 g (32.4 mmol) of bromine are added, and the mixture is stirred at 45° C. for five hours. After cooling, the mixture is filtered with suction and the filter cake is stirred with NaHCO3 solution, filtered with suction and dried. Recrystallization from ethanol is used for purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04920136 |
|---|
| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-b9bb4e605f074ba1aab4a5319bc4f9bc |
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| Source note | uspto-grants-1990_04 |
|---|
