Sodium Hydroxide → HCID 14800668, compound

HRID 2073873Notes

Reaction equation

HRID 2073873 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23]C)=[O:22])=[CH:15][CH:14]=1.[OH-].[Na+]>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14800667HCID 14800667, compound

Product 1

HCID 14800668HCID 14800668, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-(4-(2-quinolinylmethyloxy)benzyl)benzoate (0.05 mol) is heated at reflux in a 9:1 mixture of ethanol and 0.5N aqueous NaOH (450 ml). After several hours the clear reaction is evaporated. The solid residue is taken up in water and acidified. The resulting crystalline product is isolated by filtration and dried by suction with a rubber dam to obtain 3-(4-(2-quinolinylmethyloxy)benzyl)benzoic acid.

Workup

  1. customAfter several hours the clear reaction
  2. customis evaporated
  3. customThe resulting crystalline product is isolated by filtration
  4. customdried by suction with a rubber dam

Sources & evidence

ORD record
ord-1eb0a02f7d324e47b6af0d493ef3a471
Source dataset
uspto-grants-1990_04
Patent number
US04920133

Reaction notes

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