HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-(3-((Quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionate | HCID 11113252 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2-(3-((Quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionic acid | HCID 14774127 | — |
Reaction Steps
To a solution of (2.65 mmol) of the ester from step C in 25 ml of EtOH is added 10 ml (10.0 mmol, 3.75 equiv) of 1N NaOH. The mixture is stirred for 1 hour at room temperature which time the mixture is acidified to pH~4 using 1N HCl. A precipitate forms which is filtered off and recrystallized from hot MeOH-Et2O to afford 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920131 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-d7e0f0807ff44fb299122ae6caa27b5f |
| Source note | uspto-grants-1990_04 |