Potassium Carbonate → HCID 14650385, compound

Participants

Reaction Steps

A solution of (10.11 mmol) of 4-((quinolin-2-yl)methyloxy)phenol, (30.33 mmol, 3 equiv.) of 2-chloromethylbenzyl chloride and 4.2 g (30.33 mmol, 3 equiv) of K2CO3 in 100 mL of 8:1--acetone:DMF is refluxed for 24 hrs. The mixture is poured into ice-water and allowed to stand for 11/2 hours. The precipitate that forms is filtered off, redissolved in EtOAc, dried, and concentrated in vacuo. The crude product is filtered by flash column chromatography to afford 2-(4-((quinolin-2-yl)methyloxy)phenoxymethyl)benzyl chloride which is used directly in the next step.

Provenance & Evidence