HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2073902Generated: October 30, 2026
O-Cresol → Diethyl 2-(2-methylphenoxy)pentanedioate
https://huagongshe.com/reaction/2073902
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Cresol | HCID 335 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pentanedioic acid, 2-bromo-, diethyl ester | HCID 522444 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Diethyl 2-(2-methylphenoxy)pentanedioate | HCID 14774131 | — |
Reaction Steps
A mixture of o-cresol (0.1 mol) and diethyl 2-bromoglutarate (0.1 mol) and K2CO3 (0.11 mol) in 50 mL of DMF are heated at 70° C. overnight. The reaction is poured into water and extracted with ethyl acetate. The organic solution is washed with water, 0.1N NaOH solution, dried and evaporated to give ethyl 4-carbethoxy-4-(2-methylphenoxy)butyrate which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04920131 |
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| Source dataset | uspto-grants-1990_04 |
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| ORD ID | ord-a6307db3e23b4a81bc4d7be7a047ddd1 |
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| Source note | uspto-grants-1990_04 |
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