Sodium Hydroxide → HCID 14774133, compound

HRID 2073904Notes

Reaction equation

HRID 2073904 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:40]=[CH:39][C:16]([O:17][CH2:18][C:19]2[CH:38]=[CH:37][CH:36]=[CH:35][C:20]=2[O:21][CH:22]([C:30]([O:32]CC)=[O:31])[CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])=[CH:15][CH:14]=1.[OH-].[Na+]>O1CCOCC1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([O:17][CH2:18][C:19]2[CH:38]=[CH:37][CH:36]=[CH:35][C:20]=2[O:21][CH:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:39][CH:40]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19856202HCID 19856202, compound

Product 1

HCID 14774133HCID 14774133, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The crude product is purified by column chromatography to give ethyl 4-(2-(4-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)-4-carbethoxybutyrate. The ester is treated with 1N NaOH solution (30 mL) in dioxane overnight. The reaction mixture is then acidified, and purified by flash chromatography which gives 4-(2-(4-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)-4-carboxybutyric acid.

Workup

  1. custompurified by flash chromatography which

Sources & evidence

ORD record
ord-19d904310d86430b80f61dcf2bbe7616
Source dataset
uspto-grants-1990_04
Patent number
US04920131

Reaction notes

Loading…