HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,2-Bis(3-hydroxyphenyl)ethanone | HCID 14774134 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(3-(2-(3-hydroxyphenyl)2-oxoethyl)phenoxy)acetate | HCID 14774136 | — |
Reaction Steps
A mixture of 3,3'-dihydroxydeoxybenzoin (0.05 mol), ethyl bromoacetate (0.05 mol) ad K2CO3 (0.05 mol) in 50 mL of DMF is stirred at room temperature overnight. The reaction mixture is poured into water and extracted with EtOAc. The organic solution is dried and evaporated to dryness. The crude products are separtated by flash chromatography to give the ethyl 2-(3-(2-(3-hydroxyphenyl)-2-oxoethyl)phenoxy)acetate and the ethyl 2-(3-(2-(3-hydroxyphenyl)-1-oxoethyl)phenoxy)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920131 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-64e78115bf9d4228913b449b8c0205a9 |
| Source note | uspto-grants-1990_04 |