Dichloromethane → HCID 15058577, compound

Participants

Reaction Conditions

Reaction Steps

1-Hexylimidazole [304 mg (2 millimoles)] was dissolved in 2-[2-[3-octadecyloxy-2-(pyrimidin-4-yloxy)propoxy]ethoxy]ethyl methanesulfonate [800 mg (1.36 millimole)], and the mixture was heated at 80° C. for 2.5 hours. The mixture was dissolved in a mixture of dichloromethane and ethanol (95:5; 60 ml) and shaken with 30% saline for separation into layers. The lower layer collected was concentrated and purified by silica gel column chromatography [Merck, Art. 7734, 30 g (eluent: chloroform-methanol=9:1-65:25)] to give the above-identified compound [760 mg (82%)].

Provenance & Evidence