反应详情

温度

50 °C

4-Chloro-3',4'-dimethoxy benzophenone (6.29 g, 25 mmol), sodium tert.-amylate (5.50 g, 50 mmol), acetyl morpholine (23.90 g, 185 mmol), and anhydrous toluene (50 ml) were stirred under reflux for 8 hours. After cooling, the solution was washed twice with water, dried, and the toluene distilled off on a rotary evaporator. The viscous residue was stirred at 50° C. with diisopropyl ether (40 ml), whereupon the substance solidified. After it had cooled to room temperature, the crude product was crushed, filtered by suction, washed with diisopropyl ether (2×5 ml) and dried.

1. temperatureunder reflux for 8 hours
2. temperatureAfter cooling
3. washthe solution was washed twice with water
4. customdried
5. distillationthe toluene distilled off on a rotary evaporator
6. temperatureAfter it had cooled to room temperature
7. customthe crude product was crushed
8. filtrationfiltered by suction
9. washwashed with diisopropyl ether (2×5 ml)
10. customdried