HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl acetylenedicarboxylate → Dimethyl 3-thienylaminobutenedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl acetylenedicarboxylate | HCID 12980 | — |
| Reactant | Thiophen-3-amine | HCID 640543 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Dimethyl 3-thienylaminobutenedioate | HCID 56624739 | — |
Reaction Steps
3-Aminothiophene is redissolved in methanol (500 mL) cooled in an ice bath and dimethylacetylenedicarboxylate (80 g; 0.50 mol) is added dropwise. The mixture is stirred at room temperature for 15 hours and 30 minutes, the methanol removed under reduced pressure and 1,2-dichloroethane is added. This solvent is also evaporated off to give dimethyl 3-thienylaminobutenedioate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920226 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-d0712e2c99274c11bce673a9b257c770 |
| Source note | uspto-grants-1990_04 |