Isopropylamine → 2-aminooxy-N-isopropyl-acetamide

HRID 20740Notes

Reaction equation

C[O:2][C:3](=O)[CH2:4][O:5][N:6]1C(=O)C2C(=CC=CC=2)C1=O.[CH:18]([NH2:21])([CH3:20])[CH3:19]>>[NH2:6][O:5][CH2:4][C:3]([NH:21][CH:18]([CH3:20])[CH3:19])=[O:2]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 748410Methyl ((1,3-dioxo-1,3-dihydro-2H-isoindol-2-YL)oxy)acetate

Product 1

HCID 552873562-aminooxy-N-isopropyl-acetamide

Procedure

Using (1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-acetic acid methyl ester obtained in Step A of Example 19 and isopropylamine as an amine, synthesis was performed according to the procedure described in Step A of Example 20 to give 2-aminooxy-N-isopropyl-acetamide.

Sources & evidence

ORD record: ord-a883d400e1b046fa919b9cf815c9e993
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07745663B2

Reaction notes

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