HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl 3-allyl-2-methoxy-4-amino-5-chlorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-allyl-2-hydroxy-4-amino-5-chlorobenzoate | HCID 14883228 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Methyl 3-allyl-2-methoxy-4-amino-5-chlorobenzoate | HCID 14883229 | — |
Reaction Steps
A mixture of potassium carbonate (19 g), methyl iodide (8 g) and the phenolic compound of step 2 above (3.4 g) in acetone (100 ml) is stirred under reflux for about 6.4 hours. The mixture is partitioned between CH2Cl2 and H2O, and the organic layer is separated and washed with 10% aqueous HCl, dried (MgSO4) and evaporated affording an oil which chromatographed on silica gel affording the desired product which is used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920219 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-b97d88257fa240919c5e7823ce7d5bc0 |
| Source note | uspto-grants-1990_04 |