HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → alpha-(3-Chloromethylphenoxy)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-[3-(Hydroxymethyl)phenoxy]acetonitrile | HCID 11321137 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | alpha-(3-Chloromethylphenoxy)acetonitrile | HCID 14774148 | — |
Reaction Steps
α-(3-Hydroxymethylphenoxy)acetonitrile (0.055 mol) in diethylether (150 ml) is stirred with thionyl chloride (0.060 ml) and a few drops of dimethylformamide at 40° C. for 1 hr. The solution is washed with water and brine, then evaporated to give α-(3-chloromethylphenoxy)acetonitrile as a yellow oil which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04920132 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-66aa89bd7e174ccc938c806af75fcc0f |
| Source note | uspto-grants-1990_04 |