Nitric Acid → HCID 178470305, compound

HRID 2074067Notes

Reaction equation

HRID 2074067 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]([O:8][CH2:9][CH3:10])=[O:7].[N+:11]([O-])([OH:13])=[O:12]>>[N+:11]([C:5]1[N:1]=[C:2]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[NH:3][CH:4]=1)([O-:13])=[O:12]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 549404ethyl 1H-imidazole-2-carboxylate

Product 1

HCID 178470305HCID 178470305, compound

Conditions

Temperature
55 °C

Procedure

While cooling on ice, 16.08 g (114.7 mmol) of ethyl imidazole-2-carboxylate are dissolved in 71.7 ml of concentrated sulpfuric acid. 71.7 ml of 100% fuming nitric acid are then added dropwise. The reaction solution is stirred at 50 to 60° C. for 3 h and, after cooling, poured onto 800 ml of an ice/water mixture. The precipitated crystals are collected by suction filtration and washed with 1500 ml of ice-water.

Workup

  1. temperatureafter cooling
  2. filtrationThe precipitated crystals are collected by suction filtration
  3. washwashed with 1500 ml of ice-water

Sources & evidence

ORD record
ord-e8dfc7a1f2e34383acc4d6b4d36e9118
Source dataset
uspto-grants-2011_04
Patent number
US07919489B2

Reaction notes

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