HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate → Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate | HCID 59421751 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate | HCID 59421792 | — |
Reaction Steps
3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919489B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-c4b9b8d57d234046a9bf3b6c3026b5f2 |
| Source note | uspto-grants-2011_04 |