反应详情

To a solution of 1-(1-trityl-1H-imidazol-4-yl)ethanol (4.0 g, 11.3 mmol) in anhydrous 1,4-dioxane (150 mL) was added activated MnO2 (2.5 g, 28.2 mmol) at 0° C. The mixture was refluxed for 2 hours. TLC (EtOAc/Petroleum ether 1:2) showed the starting material was consumed completely, and the mixture was filtered. The filter cake was washed with dry CH2Cl2 (5×50 mL) and the filtrate was evaporated to afford the title compound (4.0 g, 100%) as a white solid.

1. temperatureThe mixture was refluxed for 2 hours
2. customwas consumed completely
3. filtrationthe mixture was filtered
4. washThe filter cake was washed with dry CH2Cl2 (5×50 mL)
5. customthe filtrate was evaporated