HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Propionate → Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Propionate | HCID 7749 | — |
| Reactant | 1-(Azidomethyl)-4-methoxybenzene | HCID 10931767 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate | HCID 12937510 | 95% |
Reaction Steps
To a solution of para-methoxy benzyl azide (125.0 g, 0.77 mol) in anhydrous DMF (300 mL) was added dropwise propionic acid ethyl ester-(166 g, 1.77 mol) at 0° C. After the addition, the mixture was stirred at RT overnight. The mixture was evaporated in vacuo to yield crude title compound (190.0 g, 95.0%) as yellow oil that was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919488B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-f50f073b7b6a4b4a8c3815c04327ab93 |
| Source note | uspto-grants-2011_04 |