Triethylamine → HCID 86620011, compound

Participants

Reaction Steps

Ethyl chlorooxoacetate (0.84 mL, 7.54 mmol) was added dropwise to a stirred solution of 4-(2-trifluoromethylbenzoyl)piperazine-1-carbothioic acid hydrazide (2.18 g, 6.56 mmol) and triethylamine in 8 mL of DMF at 0° C. over 15 minutes. The mixture was stirred for 1 hour, then 100 mL of ethyl acetate was added. The mixture was washed with water and brine, dried over anhydrous Na2SO4, and evaporated below 30° C. to dryness to yield oxo-{N′-[4-(2-trifluoromethylbenzoyl)piperazine-1-carbothioyl]hydrazino}acetic acid ethyl ester in quantitative yield (2.88 g).

Provenance & Evidence