Methyl iodide → HCID 178496592, compound

HRID 2074198Notes

Reaction equation

HRID 2074198 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:30])[N:6]2[C@H:22]1[CH2:27][CH2:26][C@H:25]([O:28][CH3:29])[CH2:24][CH2:23]1.I[CH3:32]>>[Cl:1][C:2]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[N:8]=[C:7]2[C:3]=1[N:4]([CH3:32])[C:5](=[O:30])[N:6]2[C@H:22]1[CH2:23][CH2:24][C@H:25]([O:28][CH3:29])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 178496593HCID 178496593, compound

Product 1

HCID 178496592HCID 178496592, compound

Procedure

Dark brown solid (76% crude yield). Synthesized using 3-(6-chloro-9-(trans-4-methoxycyclohexyl)-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile (0.7 g, 1.65 mmol) and iodomethane (0.61 mL, 10 mmol, 6 equiv.). MS (EI) m/z 438 (MH)+.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-4a5a8d6c3be24c08a48755d79ec0685c
Source dataset
uspto-grants-2011_04
Patent number
US07919490B2

Reaction notes

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