HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → 1-{3-[2-(4-Piperidinyl)ethyl]phenyl}urea hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | Tert-butyl 4-(2-{3-[(aminocarbonyl)amino]phenyl}ethyl)-1-piperidinecarboxylate | HCID 57507767 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-{3-[2-(4-Piperidinyl)ethyl]phenyl}urea hydrochloride | HCID 57421838 | — |
Reaction Steps
4 M hydrogen chloride/EtOAc (4 ml) was added to an EtOAc (9 ml) solution of tert-butyl 4-(2-{3-[(aminocarbonyl)amino]phenyl}ethyl)-1-piperidinecarboxylate (227 mg), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure to obtain 1-{3-[2-(4-piperidyl)ethyl]phenyl}urea hydrochloride (185 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919495B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-a17b7a653b534979a750eb2741966546 |
| Source note | uspto-grants-2011_04 |