HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2074380Generated: October 30, 2026
2-Chloropyrimidine → tert-Butyl 2-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate
https://huagongshe.com/reaction/2074380
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate | HCID 2756482 | — |
| Product | tert-Butyl 2-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate | HCID 71631688 | — |
Reaction Steps
A mixture of (RS) 2-aminomethyl-piperidine-1-carboxylic acid tert butyl ester (1.28 g) and 2-chloropyrimidine was heated at 100° C. for 48 hours. After cooling to room temperature the mixture was column chromatographed (silica gel, 0-10% (9:1 methanol/ammonia) in dichloromethane eluant) to give the title compound (0.42 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07919507B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-3274691c5b514483ad68e966f8673c86 |
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| Source note | uspto-grants-2011_04 |
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