Sodium triacetoxyborohydride → HCID 86612286, compound

Participants

Reaction Steps

Stir a suspension of N-((1R,3S)-5-methoxy-6-methyl-3-(4-piperidinyl)-1-isochromanylmethyl)formamide (1.0 mmol) with 4-Chloro-N-(1-methyl-3-oxo-propyl)-benzamide (3.0 mmol) and sodium triacetoxyborohydride (3.0 mmol) in dichloromethane (5 mL) at room temperature overnight. Apply the reaction mixture directly to a 5 g SCX column and elute and concentrate the appropriate fractions to obtain the title compound. Use the compound directly for the next step.

Provenance & Evidence